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  • 手术室中的导航仪--近红外荧光成像
    来源:http://www.moptuan.com 浏览: 发布日期:2017-11-01
    光学成像在临床医学中应用广泛,具有对人体无害、非侵入性、高灵敏度和可进行在体多目标成像的优点。其中,随着荧光显影剂的不断拓展和创新,荧光成像更是成为术中导航的要工具。
    Optical imaging is widely used in clinical medicine. It has the advantages of harmless, non-invasive, high sensitivity and multi object imaging in vivo. With the continuous development and innovation of fluorescent developer, fluorescence imaging is becoming a tool for navigation in surgery.
    荧光成像技术能够实时地显影识别手术中的目标结构和组织,定位精确,为外科医生提供清晰且易于识别的目标图像,指导手术精确进行。
    Fluorescence imaging technology can real-time identify and identify target structures and tissues in surgery, provide accurate and accurate target images for surgeons, and guide accurate operation.
    生物体内具有大量的血红蛋白、水和脂质,在650 nm-900 nm的光谱范围内吸收系数较低,该波段成为生物体的光学窗口。
    There are a large amount of hemoglobin, water and lipid in the organism, and the absorption coefficient is low in the spectral range of 650 nm-900 nm. This band becomes the first optical window of organism.
    近红外荧光成像使用近红外波段的激发光源照射荧光分子,激发出不同光谱特性的光子信号,之后信号被相机捕获,用于成像。由于近红外光的波长较长,处于生物光学窗口,吸收少,穿透深,从而提高了成像深度。
    Near infrared fluorescence imaging uses the near infrared excitation light source to irradiate the fluorescence molecules, which excites the photon signals with different spectral characteristics, and then the signals are captured by the camera for imaging. Because of the long wavelength of near infrared light, it is in the first window of biological optics, absorbs less and penetrates deeply, so as to improve the imaging depth.
    目前,基于近红外荧光显影剂吲哚菁绿的应用技术也日益成熟。该显影剂已获得FDA和CE批准,广泛应用于组织灌注、肿瘤定位、前哨淋巴结检测等诸多领域,广受好评。
    At present, the application technology of indocyanine green based on near infrared fluorescent agent is becoming more and more mature. The developer has been approved by FDA and CE. It has been widely used in many fields, such as tissue perfusion, tumor location, sentinel lymph node detection and so on.
     
    荧光显影剂吲哚菁绿通过静脉注射后,与血浆蛋白结合,通过805 nm波段左右的近红外光的激发,释放出不同波长的荧光。
    The fluorescent developer, indocyanine green, binds to plasma proteins by intravenous injection and releases different wavelengths of fluorescence through the excitation of near infrared light at about 805 nm wavelength.
    成像系统将捕捉到的荧光信号通过算法处理,在屏幕上实时地显示高清白光、荧光或叠加图像。这种实时荧光显影的方法与传统的有机染料相比,对比度更高,对目标组织的识别效果更佳,且避免了手术后期染料弥散。
    静脉药物配置中心装修
    The imaging system processes the captured fluorescence signal through the algorithm, and displays the high definition white light, the fluorescence or the superposition image on the screen in real time. Compared with the traditional organic dyes, the real-time fluorescent display method has higher contrast and better recognition effect on target tissues, and avoids dye dispersion in the later stage of surgery.
    目前,近红外荧光成像技术实现了术中实时显示荧光图像,并可根据术者需要快速切换模式,担任了术中导航的重要角色,有助于术者精确、快速实施手术。目前,该项技术主要应用有:
    At present, near infrared fluorescence imaging technology to achieve real-time display of the fluorescent image during operation, and according to the operation needs of fast switching mode, as an important role in the operation of navigation, help patients accurate and fast operation. At present, the technology is mainly used:
     
     
    妇科:内膜癌、宫颈癌、早期卵巢癌、会阴癌的淋巴结显影
    The development of lymph nodes in endometrial cancer, cervical cancer, early ovarian cancer and perineal cancer
    泌尿系统外科:肾脏肿瘤标记、前列腺切除术、前列腺淋巴结显影
    Urologic surgery: renal tumor markers, prostatectomy, and prostatic lymph node development
    肝胆外科:肝脏肿瘤边界标记、肝外胆管造影、肝脏分段造影
    Department of hepatobiliary surgery: liver tumor boundary markers, extrahepatic bile duct angiography, liver segmental angiography
    胃肠外科:胃、食管、肠管血流灌注造影、胃、肠淋巴结造影
    Gastrointestinal surgery: perfusion of the stomach, esophagus and intestine, contrast of gastric and intestinal lymph nodes
    胸外科:淋巴结显影、肺段造影
    Department of thoracic surgery: lymph node development and pulmonary angiography
    心脏外科:在体冠脉搭桥手术、离体On pump冠脉搭桥手术
    Cardiac surgery: in situ coronary artery bypass grafting and On pump coronary artery bypass grafting
    乳腺外科:乳腺癌前哨淋巴结示踪定位、乳腺癌根治术的上肢淋巴水肿预防、乳房重建皮瓣血运观测
    Breast surgery: sentinel lymph node localization in breast cancer, prevention of lymphedema in breast cancer radical mastectomy, and observation of blood flow in breast reconstruction flap
    整形外科与血管外科:穿支灌注范围测定、佳穿支的选择、微循环的检测、穿支的术中定位、皮肤及组织的血流灌注造影
    Plastic surgery and vascular surgery: the measurement of perforator perfusion range, the selection of optimal perforator, the detection of microcirculation, the location of perforator, and the blood perfusion imaging of skin and tissue
     以上文章来源于手术室装修http://www.moptuan.com

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